工程四館511室
演講大綱 清華大學材料科學工程學系
書報討論演講公告
演講者: 陳 啟 東 教授
中央研究院物理研究所教授
講 題: Detection of molecular charges using Silicon-On-Insulator based nanowire field-effect-transistors
時 間: 96年5月17日(星期四)
下午3:20~5:30
地 點: 工程四館511室
Silicon-On-Insulator (SOI) based nanowire field-effect-transistors were used to detect the molecular charges on the wire surface. The sensors hold great potential for various biomedical applications due to their intrinsic advantages in many aspects including high sensitivity with minimal requirement of the target molecules, capability for multiplex parallel processing and requiring no tedious sample labeling process. The variations of the molecular charges can be detected by measuring the changes of the wire conductance.
In this talk, we show that when incorporated with surface APTES molecules, the SOI-based silicon nanowires can act as a detector for DNA-hybridization. The high charge sensitivity of the nanowires allowed real time detection of hybridization of ssDNA with lengths as short as 15 mer, and with high degree of specificity. Details about device and microfluidic channel fabrication processes, and procedures for surface modification, DNA immobilization will be described.
